About 10% of worldwide deaths are due to traumas and 30 to 40% of those are linked to hemorrhage. During a state of hemorrhagic shock, a persistent systemic tissue hypoxia due to hypovolemia and loss of red blood cells is observed. To compensate for the lack of oxygen at tissue level, the anaerobic metabolism is activated. A lactic acidosis, the production of ROS and protons are observed thereby inducing inflammation and cell death the consequence of which can provoke patient death. Enhancing tissue oxygenation in case of hemorrhagic shock is paramount when treating patients. Hence, with Pr Y. Ozier and within the development of the trauma center (O. Grimault), our objective is to improve knowledge of the physiopathological mechanisms involved in the evolution of the hemorrhagic shock and therefore to acquire new means of diagnostic, thereby improving patient care.
ORPHY Laboratory has developed murine models of hemorrhagic shock and trauma. They allow to study the consequences of these shocks on tissue metabolism and vascular function as well as to analyse the kinetic implementation of the shock. Taking that into account, different treatment modalities are tested with a specific focus on blood substitutes. We therefore explore the efficiency of Hemoxycarrier HM-101 (extracellular haemoglobin of Arenicola marina developed by Hemarina Society) during the treatment of hemorrhagic shock.
UFR Sciences et Techniques, Université de Bretagne Occidentale
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