PHYPODE: Physiopathology of decompression : risk factors for the formation of intravascular bubbles during decompression
Coordinator: François Guerrero (ORPHY)
PHYPODE Initial Training Network is focused on "Physiopathology of decompression : risk factors for the formation of intravascular bubbles during decompression". It aims at fostering knowledge of decompression phenomena. To do so, the following objectives are proposed (Fig. 1):
1. Develop an educational and research framework for cross-fertilization of currently fragmented research activities on decompression phenomena with specific attention put into the formation of intravascular bubbles with their pathophysiological and clinical consequences.
2. Promote exchanges of fellows in mixed industrial-academic Research & Development trajectories, giving young researchers opportunities to share research techniques and resources, and jointly participate to courses, seminars, workshops and congress in order to benefit from the best international scientists knowledge in this field, get in touch with the scientific community from industry, medical centres and academic institutions, and gain complementary skills.
3. Widen career prospects of young researchers by embracing the whole chain of research applied to decompression: fundamental and clinical research, ground experimentation with professional divers, applied research in the industry for management of decompression.
Fig 1; PHYPODE Outline
Overall approach and methodology
The present understanding of the DCS mechanisms is that there are at least 3 distinct types of symptoms involved in the onset of decompression sickness. It is believed that these symptoms correspond to three different bubble scenarios:
- central or vestibular symptoms are related to the presence of a vascular bubble in the brain ;
- spinal symptoms are related to the venous damping of the vessel draining the spinal cord ;
- articular symptoms are related to the presence of a large bubble in the tendons and the ligament of the articulation.
The PHYPODE project will concentrate on the first two cases to investigate (Fig. 2):
1) mechanisms involved in intravascular bubbles formation during decompression,
2) mechanisms linking intravascular bubbles to decompression sickness.
The project unites 13 teams with their complementary competences in:
>Prospective clinical research,
>Experimental physiological approach, using fundamental and clinical research methodologies,
>Technological development for management of decompression
Mechanisms leading from decrease in ambient pressure to formation of intravascular bubbles and, then, to DCS are investigated using both epidemiological and physiological approaches, thanks to development of technological devices. On the basis of data obtained from these investigations, industrial partners will develop devices for management of decompression.
Fig 2; General frame of the research program and methodologies
UFR Sciences et Techniques, Université de Bretagne Occidentale
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29238 BREST Cedex 3 - FRANCE
Directrice : C.MOISAN (+332.98.01.62.63)
Directrice adjointe: M-A.GIROUX-METGES(+332.98.01.80.67)