Administration     Physiologie Recherche Master
L'EA 4324  ORPHY (Optimisation des Régulations Physiologiques) étudie les mécanismes physiologiques participant à l’optimisation des interactions organismes-milieu  Physiology Research Master  

Karelle Léon

Assistant-Professor in physiology, Ph. D.


Laboratoire de physiologie ORPHY (EA 4324), site Médecine
Université Européenne de Bretagne, Université de Brest
22 av Camille Desmoulins, CS 93837,
29238 BREST cedex 3

Tél: 02.98.01.65.66
karelle.leon@univ-brest.fr

 

Scientific scope / competences:

Evaluation of cytokines and antioxidant molecules effects on contraction and membrane excitability of muscular fibers in pathological conditions (sepsis, inactivity).

 

Main publications:


8- Derbré F, Droguet M, Léon K et al. 2016 Single muscle immobilization decreases single-fibre myosin heavy chain polymorphism. PlusONE. DOI: 10.1371/journal.pone.0158630       


7- Talarmin H, Derbré F, Léon K et al. 2016 Diaphragm is better protected from oxidative stress than hindlimb skeletal muscle during CLP-induced sepsis. Redox Report. DOI:10.1080/13510002.2016.1223793      

 
6- Léon K et al. 2015 Effect of induced mild hypothermia on acid base balance during experimental acute sepsis in rats. Ther Hypothermia Temp Manag, Vol 5:163-170
       
5- Léon K et al. 2015 Does induction time of mild-hypothermia influence the survival duration of septic rats? Ther Hypothermia Temp Manag, Vol 5:85-88
       
4- Léon K et al. 2013 Effect of mild-induced hypothermia on two proinflammatory cytokines and oxidative parameters during experimental sepsis. Redox report, Vol 18:120-126
       
3- Léon K et al. 2012 Oxygen blood transport during experimental sepsis: effect of hypothermia. Crit Care Med, Vol 40: 912-918.                 
       
2- Léon K et al. 2009 Effect of induced mild hypothermia upon the dynamics of sepsis progression in rat CLP model. Comp Biochem and Physiology, part A153:107-108
       
1- Hymery N, Léon K et al. 2009 T-2 toxin inhibits differentiation of human monocytes into dendritic cells and macrophages. Toxicology in Vitro, Vol 23: 509-519     

 

 

Laboratoire ORPHY
UFR Sciences et Techniques, Université de Bretagne Occidentale

6 Av. Le Gorgeu  -  CS 93837
  29238 BREST Cedex 3   -   FRANCE

Directrice : C.MOISAN (+332.98.01.62.63)
Directrice adjointe: M-A.GIROUX-METGES(+332.98.01.80.67)
recherche@physiology-orphy.fr

 


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