Administration     Physiologie Recherche Master
L'EA 4324  ORPHY (Optimisation des Régulations Physiologiques) étudie les mécanismes physiologiques participant ŕ l’optimisation des interactions organismes-milieu  Physiology Research Master  

Michael Droguet


Laboratoire de physiologie ORPHY, site Médecine
22 av Camille Desmoulins, CS 93837,
29238 BREST cedex 3



Scientific scopes/Competences:

Study of sepsis with in vivo and in vitro approach on rat striated muscle fibers and study of the potential protective effect of halophyte extracts selected for their antioxidant properties


Main publications:

Droguet M., Devauchelle, N., Pennec J.P., Quinn B., and Dorange G. (2012). Cultured heart cells from oyster: an experimental approach for evaluation of the toxicity of the marine pollutant tributyltin. Aquat. Living Resour. 25, 185–194    

Guillouet M, Rannou M., Giroux-Metges M.G., Droguet M. and Pennec J.P. (2013). Tumor Necrosis Factor alpha induced hypoexcitability in rat muscle evidenced in a model of ion currents and action potential corresponding. Cytokine. 64(1)165-171.

Guillouët M. ; Moha
mmed Saïd K.; Droguet M.; Rannou F.; Pennec J.P. and Giroux-Metges M.A (2013) Sepsis and tumor necrosis factor-alpha alter the contractile properties and fatigability of rat diaphragm. Fundamental & clinical pharmacology. 27: 86

Derbré F., Droguet M., Léon K., Troadec S., Pennec J.P., Giroux-Metges M.A. et Rannou F. (2016) Single Muscle Immobilization Decreases Single-Fibre Myosin Heavy Chain Polymorphism: Possible Involvement of p38 and JNK MAP Kinases. PloS One 11(7):1-16

Talarmin H., Lefeuvre L., Droguet M., Giroux-Metges M.A., Pennec J.P., Leon K. and Derbré F. (2016)  Diaphragm is better protected from oxidative stress than hindlimb skeletal muscle during CLP-induced sepsis. Redox Report 6:1-9

Bettaib J., Talarmin H., Droguet M., Magné C., Boulaaba M., Giroux-Metges M.A. and Ksouri R. (2017)Tamarix gallica phenolics protect IEC-6 cells against H 2 O 2 induced stress by restricting oxidative injuries and MAPKs signaling pathways. Biomed Pharmather 89: 490-498.

Jaballi I, Saad H.B., Bkhairia I, Kammoun I, Droguet M, Magné C, Boudawara T, Kallel C, Nasri M, Hakim A and Ben Amara I (2017). Increasing maneb doses induces reactive oxygen species overproduction and nephrotoxicity in adult mice. Toxicol Mec Method 27(5): 382-393




Laboratoire ORPHY
UFR Sciences et Techniques, Université de Bretagne Occidentale

6 Av. Le Gorgeu  -  CS 93837
  29238 BREST Cedex 3   -   FRANCE

Directrice : C.MOISAN (+332.
Directrice adjointe: M-A.GIROUX-METGES(+332.


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