Administration     Physiologie Recherche Master
L'EA 4324  ORPHY (Optimisation des Régulations Physiologiques) étudie les mécanismes physiologiques participant ŕ l’optimisation des interactions organismes-milieu  Physiology Research Master  


Optimization of Physiological regulations

Director: Christine Moisan
Co-director: Marie-Agnès Giroux-Metges

The team is constituted by 36 members:

  • 19 professors and associate professors from several faculties of UBO (Sciences, Medicine, Sport Sciences, Humanity and Social Sciences, University Institute of technology)
  • 3 medicine practitioners from the hospital, 1 hospital and research assistant
  • 6 (2.5 Full-Time Equivalent) technical and administrative members
  • 7 PhD students (2018, january 1st)

Our research activity is part of the Challenge 4 "Health and Welfare" as defined by the National Research Strategy France Europe 2020. Our investigations concern  cardiovascular and muscular adaptations with the main objective of improving  prevention and therapy in human. The main mechanisms studied concern metabolic  (bioenergetics, inflammation, reactive oxygen species etc…), electrophysiological (ionic currents and excitability) and mechanical (contractility) aspects related to vascular and/or muscular functions. Studies are performed in various physiological and physiopathological conditions (see “research projects” sections).

The current research projects focus on:

  • Physiopathology of decompression sickness
  • Management and prevention of cardiovascular diseases
  • Hemorrhagic shock
  • Sepsis and polyneuromyopathy
  • Myalgia and exercise intolerance. Muscle fatigue
  • Mechanisms of skeletal muscle adaptation to under-utilization or disuse (immobilization)







Laboratoire ORPHY
UFR Sciences et Techniques, Université de Bretagne Occidentale

6 Av. Le Gorgeu  -  CS 93837
  29238 BREST Cedex 3   -   FRANCE

Directrice : C.MOISAN (+332.
Directrice adjointe: M-A.GIROUX-METGES(+332.


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